ABSTRACT
The similarity of disease and possible translation value varies considerably and in some circumstances multiple animal species may provide a more robust approach to the study of a particular disease than focusing on a single species model. A systematic approach of presenting comparable diseases of large animals and man will be made mainly by organ system. Naturally occurring osteoarthritis is a common disease in horses and other large animal species. Horses develop osteoarthritis both in their domesticated and wild environments. The common athletic use of the horse allows for the assessment of rehabilitation and exercise programs on the progression of disease or in response to an intervention. Osteochondrosis is a commonly recognized and relatively well-studied disease in large animal species, particularly horses and pigs. The economic consequences of the disease in these species and its relatively high prevalence have prompted ongoing investigation into its pathogenesis and potential therapeutic or preventative interventions.
