ABSTRACT
Sarcomatoid squamous cell carcinoma (SSCC) is an aggressive, highly malignant variant of SCC, with the capacity to give local or distant metastases. It tends to occur in older men on skin exposed to solar or ionizing radiation, predominantly on the head and neck. Its clinical appearance is unspecific (single, firm, ulcerated, reddish nodule, with a quite rapid growth) and the diagnosis usually requires histopathologic examination and immunohistochemistry. The treatment of choice is the wide surgical excision. There is little knowledge about any specific dermatoscopic features of SSCC: the evidence reports a prevalent red color with a polymorphous vascular pattern, white structureless areas, yellow to light-brown opaque scales and microerosions/ulcerations. SSCC may resemble dermoscopically a poorly differentiated SCC.
