ABSTRACT
Abstract ................................................................................................. 172 6.1 Introduction .................................................................................. 172 6.2 Preparation Techniques and Bioapplications of Porous
Polymeric Particles ...................................................................... 176 6.3 Conclusions and Future Perspectives .......................................... 202 Acknowledgments ................................................................................. 202 Keywords .............................................................................................. 203 References ............................................................................................. 203
SILVIA VASILIU1*, STEFANIA RACOVITA1, CRISTINA DOINA VLAD1, IONELA GUGOASA2, and MARCEL POPA2,3
1“Mihai Dima” Functional Polymers Department, “Petru Poni” Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley No 41A, 700487 Iasi, Romania 2Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iasi, Prof. Dr. Docent Dimitrie Mangeron Street, No. 73, 700050 Iasi, Romania 3Academy of Romanian Scientists, Spaiul Independentei Str. 54, 050094 Bucuresti, Romania
*Corresponding author. E-mail: msilvia@icmpp.ro
ABSTRACT
Porous particles that possess external/internal pores or a combination of both have received a great attention in last decades due to their potential applications in healthcare as carriers for biomacromolecules and other substances, bone tissue engineering and regeneration, pulmonary drug delivery, cell therapy, and dental applications. Porous particles can be obtained from a large variety of natural and synthetic polymers having access to different manufacturing processes like suspension, dispersion, precipitation, multistage, membrane/microchannel emulsification, and microfluidic polymerization. The porous particles possess the excellent properties like greater surface area, lower mass density, superior cell attachment and cell proliferation, higher drug absorption, and appropriate drug release kinetics for desired applications. Also, the use of particulate systems in biomedical applications confers a series of facilities: permits the election and formulation of different combinations polymer-active principle, offers a gradual release of the bioactive principle in such manner as to provide the desired results, allows a diversification in the administration routes, such as oral, transdermal, ophthalmic, nasal, anal, and vaginal administrations.
