ABSTRACT
Numerous experiments, both in vitro and in vivo, have to be performed before a biomedical application is put to practical use in the clinical environment. As a complementary work to in vivo experimenting, analytical and numerical models can be used to represent, as realistically as possible, real biological phenomena. In this way, we can better understand some of the processes involved and analyze and explain the experimental results. Di erent electrical parameters can be evaluated in advance, such as pulse amplitude, duration, and number of pulses. All of that can help us plan new protocols, design electroporation devices, facilitate the design of electrodes and their placement with respect to target tissue, and plan new experiments and treatments (Šemrov and Miklavčič 1998, Brandisky and Daskalov 1999,
15.1 Introduction ......................................................................................299 15.2Electromagnetic Field eory........................................................ 300
15.5 Treatment Planning ..........................................................................315 15.6Summary............................................................................................ 318 Acknowledgments........................................................................................ 318 References...................................................................................................... 318
Miklavčič et al. 2000, Dev et al. 2003, Miklavčič et al. 2006a, Šel et al. 2007, Čorović et al. 2008b, Županič et al. 2008). Of course, models have to be validated by experiments and, if necessary, improved. Experimenting with such models is easier and sometimes the only possible or ethically acceptable alternative to experimenting on real biological systems. Both experimental work and numerical modeling combined give us valuable information and help us to understand the underlying mechanisms of the process(es) we are aiming to describe.
