ABSTRACT
In this chapter, we discuss the principles of dižuse optical tomography (DOT) imaging using continuous wave (CW) and frequency domain (FD) measurement systems. Section 19.2 describes the instruments and imaging con›gurations commonly used for acquiring CW and FD data. ™e numerical approaches to transforming the measured data into meaningful images in tissue are also discussed in Section 19.2, and the importance of resolving the spectral content of the reemitted light to extract physiologically relevant parameters is described. ™ese measurements can be used to reduce inaccuracies in the ›nal image caused by coupling errors, but also facilitate the direct recovery of oxyhemoglobin (HBO) and deoxyhemoglobin (Hb) concentration, water and lipid content, ežective scatterer size, and density (using Mie theory) in the image. In addition to spectral content, cutting-edge systems are being developed to couple DOT systems with non-optically based medical imaging devices, such as MRI and ultrasound. Several methods to couple the data sets from these hybrid imaging systems are described.
