ABSTRACT
In•ammation is an important process that involves immune cell activation and production of in•ammatory signals. In•ammation is a natural and necessary response of the body to injury or infections and in•ammatory signals play an important role in recruiting immune cells to the site of the injury to clear out pathogens. However, dysregulated in•ammation can contribute to a number of pathologies including diabetes [27], liver brosis/cirrhosis [19], and cancer [8]. The connection between in•ammation and cancer has drawn considerable attention recently [5,6]. While the causative link between in•ammation and cancer is still tenuous, studies have suggested that treatment with anti-in•ammatory drugs can signicantly reduce cancer risk [4]. Other studies described functional impairment of T-cells in patients with malignant tumors [7]. Given the importance of in•ammation in cancer formation and metastasis, the immune cells that produce in•ammatory signals are likely to become either targets of anticancer therapies or diagnostic correlates of cancer progression. Importantly, histological analysis of
22.1 Introduction .................................................................................................................................. 389 22.2 Materials and Methods..................................................................................................................391
