ABSTRACT
Thyroid cancer is a cancerous growth of the thyroid gland and the most common endocrine malignancy, accounting for approximately 1% of malignancies worldwide [1]. Thyroglobulin (Tg) concentration in blood is a key parameter in the follow-up of patients treated for differentiated thyroid cancer (DTC) [2]. The power of Tg detection lies in the fact that Tg can only be made by the thyroid gland. Tg is a very specic protein biomarker and can be used for prognosis after the eradication of normal thyroid tissue in thyroid cancer patients. Up to 20% of patients with initial treatment of thyroidectomy and radioablation therapy show subsequent persistence or recurrence of the disease, and 8% of them eventually die [3]. Thus, highly sensitive and selective tools to detect Tg are useful for the persistent and recurrent disease.
