ABSTRACT
Figure 2. Types of clustered damage. There are non-DSB and DSB clusters. Non-DSB clusters can contain base damage, AP sites and SSBs situated on the same strand in tandem or separated by a few bases, or the damage can be in opposing strands. Tandem intrastrand crosslinks are also generated by ionizing radiation on the DNA. DSBs can be simple or complex. The complex DSBs are DSBs with near-by oxidative damage. B on the DNA structure represents a base damage or AP site.
