ABSTRACT
Work in the Harrison lab is supported by NCI grant numbers CA085693 and CA085693-09S1.
DSB : double strand break LMDS : locally multiply damaged sites SSB : single strand break LET : linear energy transfer BER : base excision repair NER : nucleotide excision repair HR : homologous recombination NHEJ : non-homologous end joining 8oxodG : 8-oxo-7,8-dihydro-2’-deoxyguanine TG : thymine glycol DHU : dihydrouracil AP : abasic site 5OHC : 5-hydroxycytosine 5OHU : 5-hydroxyuracil 5OHMeU : 5-hydroxymethyluracil FAPYG : 2,6-diamino-4-hydroxy-5-formamidopyrimidine 8oxoA : 8-oxo-7,8-dihydroadenine AP : abasic L : 2-deoxyribonolactone (oxidized abasic site) dF : formylamine furan : tetrahydrofuran U : uracil 5mC : 5 methylcytosine ^ : intrastrand crosslink DHT : 5,6-dihydrothymine P : phosphate PG : phosphoglycolate EndoIII : endonuclease III EndoIV : endonuclease IV Fpg : formamidopyrimidine DNA glycosylase Ogg1 : human Ogg1 Ape1 : human major AP endonuclease PNKP : polynucleotide kinase phosphatase
ExoIII : exonuclease III mOgg1 : mouse Ogg1 yOgg1 : yeast Ogg1
Adar, S., L. Izhar, A. Hendel, N. Geacintov, and Z. Livneh. 2009. Repair of gaps opposite lesions by homologous recombination in mammalian cells. Nucleic Acids Res. 37: 5737-5748.
