ABSTRACT
The structural diversity of material surfaces in contact with biological organisms such as cells, tissue, and the extracellular matrix (ECM) can dictate the proliferation, differentiation, and overall behavior of cell function. This chapter presents a generalized summary of nanostructured biointerfaces and their synthesis. It focuses primarily on the properties of nanostructured biointerfaces and the process–structure–property (PSP) relationship strategies to design them. The chapter summarizes key biofunctional properties that dictate both their function and behavior. It explores several emergent biotechnological applications with respect to the design of nanostructured biointerfaces. Biomedical applications frequently require the use of biomaterials in the fabrication of devices and implants in order to improve the behavior of an organ or tissue, or, sometimes, for its replacement. With the aim of designing optimum biointerfaces for biomedical applications, the chapter addresses the global biomaterial/tissue system, as well as the specific roles and interactions of the interfaces associated with given design requirements.
