ABSTRACT
aTargeting of therapeutic enzymes is a challenge and is the subject of current study. See Ribeiro, C.C. Barrias, C.C., and Barbosa, M.A., Calcium phosphate-alginate microspheres as enzyme delivery matrices, Biomaterial 25, 4363–4373, 2004; Vogler, C., Levy, B., Grubb, J.H., et al., Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII, Proc.Nat.Acad.Sci.USA 102, 14777–14782, 2005; Fukudo, T., Ahearn, M., Roberts, A., et al., Autophagy and mistargeting of therapeutic enzymes in skeletal muscle in Pompe disease, Mol.Ther. 14, 831–839, 2006; Lee, S., Yang, S.C., Hefferman, M.J., et al., Polyketal microparticles: a new delivery vehicle for superoxide dismutase, Bioconjug.Chem. 18, 4–7, 2007.
