ABSTRACT
This chapter presents the results of specific practical studies of colloidal gold nanoparticles (AuNPs) interaction with various small molecules and biomolecules and their application for localized surface plasmon resonance (LSPR)-based sensing and drug development. The first study deals with the characterization of colloidal AuNPs-biomolecules interaction in the view of a search for optimal LSPR sensor response modes, resulting in an experimental confirmation of theoretically predicted LSPR sensor response enhancement. The second study is focused on the experimental and theoretical characterization of small-molecules-induced aggregation of AuNPs, revealing how the differences between and combinations of functional groups in those molecules could promote the aggregation process to achieve a high-sensitive sensor platform. The third study reports on spectrophotometric characterization of interactions in the multicomponent doxorubicin-bovine serum albumin-AuNPs system, providing insights on the design of potential prodrugs with regulated properties of antibiotic and protein complexation.
