ABSTRACT
Applications of biosensors increased signi‘cantly in parallel with the development of the microprocessor-applied technology and rapid growth of biotechnology. These applications vary in different areas such as medical, food, environmental, military, and so forth. Considering food technology in particular, the biological and chemical contaminants should be determined, for they are of crucial importance for food safety and quality. Conventional methods applied for the determination of these components have some drawbacks when compared with biosensors. These procedures involve a series of time-consuming steps and bulky devices including separative techniques coupled to various detectors such as gas chromatography (GC), highperformance liquid chromatography (HPLC), mass spectrometer (MS), ultraviolet
3.1 Introduction .................................................................................................... 71 3.2 Detection Scheme of Quartz Crystal Microbalance (QCM) .......................... 73 3.3 Assay Format of QCM .................................................................................... 74 3.4 Applications of QCM in Food Analysis ......................................................... 75 3.5 QCM Immunosensor for Histamine ............................................................... 76
3.5.1 Modi‘cation of Quartz Crystal Surfaces............................................ 76 3.5.1.1 Chemical Treatment ............................................................. 76 3.5.1.2 Plasma Polymerization .........................................................77
