ABSTRACT
A small direct current (DC) voltage imposed across a nanopore merged in an aqueous electrolyte generates an ionic current flowing through the pore. The induced ionic current is sensitive to the size and shape of the nanopore. A nanoparticle, such as a DNA molecule, passing through a nanopore by electrophoresis will modulate the ionic current through the pore, yielding information on the translocating nanoparticle through the change of the recorded ionic current signal. Nanopore-based sensing has the potential to become a direct, fast, and inexpensive DNA sequencing technology.
