ABSTRACT
LPD is a low-temperature, low-cost, and reliable method to prepare
organic/inorganic hybrid materials. In the combination with
molecular imprinting, selective molecular recognition activity for
target proteins can be introduced, and applied to sensing systems,
•‡’ƒ”ƒ–‹‘‡†‹ƒǡƒ†ƒ”–‹ϐ‹…‹ƒŽ”‡…‡’–‘”•Ǥ
Protein-recognition/sensing materials have become of great
interest, since many proteins in biological systems act as biomarkers
–Šƒ– ’Žƒ› ‡› ”‘Ž‡• ‹ –Š‡ ϐ‹‡Ž† ‘ˆ ’”‘–‡‘‹…•Ǥ – ‹• ™‡ŽŽǦ‘™ that biomacromolecules such as antibodies and enzymes are
employed to detect proteins and discover unknown biomarkers
from biological systems. However, such biomacromolecules are
•‘‡–‹‡•†‹ˆϐ‹…—Ž– –‘ ϐ‹†ƒ†Ȁ‘”—–‹Ž‹œ‡ǡ†—‡ –‘Š‹‰Š…‘•– ˆ‘” –Š‡ production and low stability under the harsh conditions. Therefore,
synthetic materials capable of protein-recognition/sensing activity
have been intensively studied as substitutes for biomacromolecules.
Template polymerization techniques such as molecular imprinting
