ABSTRACT
References 238
1. INTRODUCTION
Hirschsprung disease is characterized by the absence of ganglion cells in the myenteric
and submucosal plexuses. Usually, the abnormality involves the rectosigmoid region,
but in some cases it may extend proximally to involve the entire colon or even some of
the small bowel. The absence of intrinsic innervation results in disturbed motility, with
resultant neonatal bowel obstruction, constipation, or enterocolitis.