ABSTRACT

Cancer is a serious medical and social problem throughout the world. However, there remain many problems with cancer chemotherapy agents; foremost of these is their high toxicity. After systemic injection, anticancer drugs distribute throughout the

14.1 Introduction .................................................................................................. 229 14.2 Folate-Linked Particles ................................................................................. 231

14.2.1 Folate-Linked Nanoemulsions .......................................................... 231 14.2.2 Folate-Linked Polymer Micelles ...................................................... 231 14.2.3 Folate-Linked Liposomes ................................................................. 232 14.2.4 Folate-Linked Liposomes Combined with Anti-Angiogenesis

Reagents ............................................................................................ 233 14.2.5 Folate-Linked Liposomes with Endosomal Release ........................234 14.2.6 Folate-Linked Nanoparticles ............................................................234