ABSTRACT
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References..................................................................................................................................... 529
Technological advancements in recent years have introduced various in vivo imaging
modalities for the study of living organisms, including those suitable for cellular imaging.
Positron emission tomography (PET) [1], bioluminescent imaging [2], single photon emission
tomography (SPECT) [3], and MRI [4] are all suitable to track labeled cells, with MRI having
superior temporal and spatial resolution. Tracking cells using MRI relies on biocompatible MR
contrast agents allowing repetitive monitoring of targeted cells. The rapidly growing stem cell
field has recognized in vivo cell visualization as a valuable tool to study the biology of stem
cells, as well as a noninvasive method for in vivo monitoring, which may also facilitate proper
translation of stem cell-based therapies into the clinical setting. Stem cell therapy is currently
being evaluated as a possible treatment for numerous diseases, with an emphasis on brain or
cardiac disorders for which an effective therapy is lacking.
