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14 Pages

Androgen receptor expression in endometrial cancer

Androgens are aromatized to estrogens in several tissues, including the endometrium. During menopause, extraglandular production of estrogens may play a role in the development of certain forms of endometrial carcinoma that depend on estrogenic stimulation for their growth. Therefore, local intratumor aromatization of androgens may play a critical role in stimulating the growth of estrogen-dependent endometrial carcinomas.