ABSTRACT
The measurement of DNA variation between individuals in the form of length or sequence polymorphisms plays an important role in a number of fields, including medical diagnostics, agricultural genomics, genetic mapping and linkage studies, and human identity testing and forensics. The growth in these fields and the demand for high-throughput typing information has generated considerable interest in the use of multicolor fluorescence technology. In addition, the introduction of multicapillary electrophoresis systems has improved automation and ease of use over previous gel electrophoresis approaches.1 The combination of multicolor fluorescence and multicapillary instrumentation was integral to the accelerated pace of the Human Genome Project in recent years1 and the earlier than expected completion of the first draft sequence of the human genome.2
