SARs and QSARs of Mutagens and Carcinogens: Understanding Action Mechanisms and Improving Risk Assessment

Carcinogenicity ................................................................................271 9.5 Different Databases: Pharmaceutical Drugs vs. General Chemicals ..........275 9.6 Conclusions ..................................................................................................277 References..............................................................................................................278

A huge and constantly expanding effort has developed to understand the interactions between chemicals and living organisms in regard to pharmaceutical drugs, pesticides, and toxic chemicals. For the last 40 years, the science of quantitative structure-activity relationships (QSAR) has improved our understanding of the chemicobiological interactions in mathematical terms.