ABSTRACT
The interaction between cells and surfaces plays a major biologic role in cellular behavior. Cell membrane receptors responsible for adhesion may influence cell physiology in numerous ways. Examples of these interactions are the rolling and activation of leukocytes on vascular endothelium, the spatial differentiation of embryonic basement membranes in development, the extension of neurites on adhesion proteins, the proliferation of cells induced by mitogenic factors, and the spreading and recruitment of platelets onto the vascular subendothelium. These and other cell-surface interactions influence or control many aspects of cell physiology, such as adhesion, spreading, activation, recruitment, migration, proliferation, and differentiation.
