ABSTRACT

In the middle of the 18th century, Hunter (1757) (1) and Petit (1774) (2) developed the first systematic description of human vascular anomalies. During the next century, the works of Hooper (1841) (3), Bell (1815) (4), and Virchow (1863) (5) led to further terminology to describe vascular lesions. A more rational analysis was later developed by Reinhoff (6) and Malan (7), who based developmental pathogenesis on errors in embryogenesis that occur at specific time points and their consequences on vasculogenesis. Their efforts led to a classification system of vascular anomalies with four categories on the basis of developmental considerations: capillary, venous, arteriovenous, and troncular arteriovenous anomalies.