ABSTRACT

I. Introduction ..................................................................................................167 II. The Nonadrenergic Noncholinergic Airway Innervation ............................168 III. Neurogenic Airway Inflammation ...............................................................170 IV. Neuronal and Nonneuronal Sources of Tachykinins in Human Airways....171 V. Airway Tachykinin Receptors......................................................................172 VI. Bronchoconstrictor Effects of Tachykinins .................................................173 VII. Tachykinins and Airway Plasma Extravasation...........................................174 VIII. Role of Tachykinins in Animal Models of Asthma and Chronic

Obstructive Pulmonary Disease ...................................................................175 IX. Tachykinin Receptor Antagonists as a Potential New Treatment for

Obstructive Airway Diseases .......................................................................176 Further Reading .....................................................................................................177