ABSTRACT
It is recognized that standard ICP-MS instrumentation using a traditional sample introduction system composed of a spray chamber and nebulizer has certain limitations, particularly when it comes to the analysis of complex samples. Some of these known limitations include
• Total dissolved solids must be kept below 0.2%. • Long washout times required for samples with a heavy matrix. • Sample throughput is limited by the sample introduction process. • Contamination issues with samples requiring multiple sample preparation steps. • Dilutions and addition of internal standards can be labor intensive and time-
consuming. • If matrix has to be removed, it has to be done off-line. • Matrix suppression can be quite severe with some samples. • Matrix components can generate severe spectral overlaps on analytes. • Organic solvents can present unique problems. • The analysis of solids and slurries is very difficult. • Not suitable for the analysis of elemental species or oxidation states.
