ABSTRACT
The cholinergic system is closely involved with normal BG function and hence with its pathology.8 While it has been suggested that a relatively simple balance between acetylcholine (ACh) and dopamine is essential for normal BG function, the involvement of the cholinergic system in PD is multifaceted. Thus, whereas cholinergic antagonists can alleviate motor symptoms,9 presumably by restoring the ACh/ dopamine balance within the striatum, cortical cholinergic deficiencies may underlie the cognitive impairments in PD.10
