ABSTRACT
Trade names: Aggrenox (Boehringer Ingelheim); Alka-Seltzer; Anacin (Wyeth); Ascriptin (Novartis) (Wallace); Aspergum; Coricidin D; Darvon Compound (aaiPharma); Ecotrin (GSK); Empirin; Equagesic (Women First); Excedrin (Bristol-Myers Squibb); Fiorinal (Watson); Gelprin; Halfprin; Measurin; Norgesic (3M); Robaxisal; Soma Compound (MedPointe); Talwin Compound (Sanofi-Aventis); Vanquish Other common trade names: ASA; Aspro; ASS; Bex; Caprin; Claragine; Disprin; Ecotrin; Novasen; Rhonal Indications: Pain, fever, inflammation Category: Nonsteroidal anti-inflammatory (NSAID) analgesic; Salicylate Half-life: 15-20 minutes Clinically important, potentially hazardous interactions with: bismuth, boswellia, capsicum, cholestyramine, devil’s claw, dicumarol, etodolac, evening Primrose, ginkgo biloba, ginseng, heparin, ibuprofen, indomethacin, ketoprofen, ketorolac, methotrexate, phellodendron, resveratrol, reteplase, sermorelin, sulfites, tirofiban, urokinase, valdecoxib, valproic acid, verapamil, warfarin
Aggrenox is aspirin and dipyridamole
Reactions
Skin Acute generalized exanthematous pustulosis (AGEP) [1]
Allergic reactions (sic) (<1%) (with dipyridamole) [1]
Angioedema (1-5%) [21] Baboon syndrome [1] Bullous eruption (<1%) [4] Dermatitis herpetiformis [1] Dermatomyositis [1] Diaphoresis Erythema multiforme (<1%) [9] Erythema nodosum (<1%) [9] Erythroderma [1] Exanthems [11] Exfoliative dermatitis [1] Fixed eruption (<1%) [21] Flushing [1] Genital herpes [1] Graft-versus-host reaction [1] Granulomas [1] Herpes simplex [1]
Lichenoid eruption [2] Parapsoriasis [1] Pemphigus [1] Petechiae [1] Photo-recall [1] Pigmented purpuric eruption [1] Pityriasis rosea [2] Pruritus [6] Psoriasis [2] Purpura [7] Pustular psoriasis [2] Rash (sic) (1-10%) Stevens-Johnson syndrome [4] Toxic epidermal necrolysis (<1%) [9] Ulcerations (<1%) (with dipyridamole) Urticaria (1-10%) [62] Vasculitis [3]
Hair Hair – alopecia [1]
Eyes Ocular hemorrhage [1] Periorbital edema [3]
Aphthous stomatitis [3] Dysgeusia Gingivitis (<1%) (with dipyridamole) Headache Hypersensitivity [3] Myalgia (1.2%) (with dipyridamole)
Oral ulceration [4] Paresthesias (<1%) (with dipyridamole) Pseudolymphoma [1] Pseudoporphyria [1] Tinnitus
Trade names: Tenoretic (AstraZeneca); Tenormin (AstraZeneca) Other common trade names: Antipressan; Apo-Atenol; AteHexal; Atendol; Evitocor; Noten; NovoAtenol; Nu-Atenol; Taro-Atenol; Tenolin; Tenormine Indications: Angina, hypertension, acute myocardial infarction Category: Antianginal; Antihypertensive; Beta-adrenoceptor blocker Half-life: 6-7 hours (adults) Clinically important, potentially hazardous interactions with: alfuzosin, clonidine, epinephrine, verapamil
Tenoretic is atenolol and chlorthalidone
Reactions
Skin Acrocyanosis [1] Dermatitis [1] Diaphoresis Edema Erythema multiforme Exanthems Facial edema Fixed eruption [1] Grinspan’s syndrome* [1] Hyperkeratosis (palms and soles) Lichenoid eruption [1] Lupus erythematosus [2] Necrosis [3] Papulo-nodular lesions [1] Photosensitivity Pityriasis rubra pilaris [1] Pruritus (1-5%) Psoriasis [7] Purpura
Pustular psoriasis [1] Rash (sic) [1] Raynaud’s phenomenon [1] Toxic epidermal necrolysis Urticaria [2] Vasculitis [1] Vitiligo Xerosis
Hair Hair – alopecia [1]
Nails Nails – dystrophy Nails – onycholysis Nails – pigmentation Nails – splinter hemorrhages [1]
Eyes Oculo-mucocutaneous syndrome [1]
*Note: Grinspan’s syndrome: the triad of oral lichen planus, diabetes mellitus, and hypertension
Trade name: Lipitor (Pfizer) Indications: Hypercholesterolemia Category: Antihyperlipidemic; HMG-CoA reductase inhibitor Half-life: 14 hours Clinically important, potentially hazardous interactions with: azithromycin, bosentan, clarithromycin, cyclosporine, erythromycin, fosamprenavir, gemfibrozil, imatinib, itraconazole, niacin, telithromycin, verapamil
Reactions
Skin Acne (<2%) Allergic reactions (sic) (<2%) Cheilitis (<2%) Dermatitis (<2%) Dermatomyositis [1] Dermographism [1] Diaphoresis (<2%) Eczema (<2%) Edema (<2%) Exanthems Facial edema (<2%) Flu-like syndrome Lichenoid eruption [1] Linear IgA dermatosis [2] Lymphocytic infiltration [1] Petechiae (<2%) Photosensitivity (<2%) Pruritus (<2%) [1] Rash (sic) (>3%) [1] Seborrhea (<2%) Toxic epidermal necrolysis [1] Ulcerations (<2%) Urticaria (<2%) [1]
Xerosis (<2%)
Hair Hair – alopecia (<2%) [6]
Hematopoietic Ecchymoses (<2%)
Other Ageusia (<2%) Death [1] Dysgeusia (<2%) Glossitis (<2%) Gynecomastia (<2%) Headache Limb pain [1] Myalgia (>3%) [13] Myositis [2] Oral ulceration (<2%) Paresthesias (<2%) Parosmia (<2%) Polyneuropathy [2] Rhabdomyolysis [9] Stomatitis (<2%) Tendinitis [1]
