ABSTRACT
The classic multihit hypothesis of tumorigenesis and the intricacies of molecular signaling pathways point to the complex biology involved in the development and growth of malignant epithelial cells. Until recently, molecular technologies only permitted the evaluation of a small group of genes or a particular signaling pathway at a given time.With the development of microarray technology, the opportunity to obtain a system-wide understanding of the machinery of a tumor cell is now possible.
