ABSTRACT
The insulin resistance syndrome (IRS), otherwise known as the metabolic syndrome (MS) or syndrome X, is made up a constellation of cardiovascular and metabolic risk factors, all of which have been shown to be associated with cardiovascular disease (CVD)1
as well as all-cause death.2,3 Such factors have been mainly identified as: glucometabolic abnormalities (type 2 diabetes (DM2)), impaired glucose tolerance, or impaired fasting glucose), insulin resistance (IR), visceral obesity, dyslipidemia, hypertension, and altered blood coagulation. The central building stone of the IRS is a more generalized metabolic disorder known as insulin resistance, to which all individual components are linked. In fact, IR has been considered the unifying hypothesis for describing the pathophysiology of the IRS. In the next part of this chapter, we will focus our discussion on the link between age-related IR and the individual components of the IRS.
