ABSTRACT
The vascular system is vulnerable to thrombus formation, which may lead to partial or complete interruption of blood flow and may cause tissue hypoxia and result in tissue loss. Therapies aimed at thrombus dissolution are of paramount importance in vascular and endovascular medicine. Fibrinolytic agents have historically been considered the archetype of the thrombus dissolving agents, and have been shown to be of great clinical utility in almost every vascular territory.
