ABSTRACT

Infertility and birth defects are often the result of chromosomal abnormalities in gametes1-3, with more than 80% of cases being paternally derived4. The development of multicolor fluorescence in situ hybridization (FISH) has allowed detection and analysis of several types of chromosomal defects in sperm, such as aneuploidies, partial chromosomal duplications, deletions and inversions, translocations and chromosomal breaks2,5-7.