ABSTRACT
Male infertility is a relatively common complaint that affects approximately one in 20 men in developed countries. Despite the prevalence of this condition, relatively little is known about the underlying pathophysiology. Indeed, since the advent of intracytoplasmic sperm injection (ICSI) as a therapeutic technique in 19921, the biomedical community has paid little attention to this problem. However, an appreciation of the etiology of male infertility will be essential if we are to optimize procedures for the management of this condition and contemplate strategies for its possible prevention.
