ABSTRACT
It is estimated that male subfertility is present in up to 40-50% of infertile couples, alone or in combination with female factors1,2. There has been extensive progress in the diagnosis and treatment of male factor infertility since the inception of assisted reproductive technologies (ART). Moreover, the advent of intracytoplasmic sperm injection (ICSI) has resulted in a dramatically increased likelihood of pregnancy in couples suffering from most causes of male infertility. Fundamental advances have been made in the genetics of male disorders. Nevertheless, and at the same time, we are now witnessing a steady state in the development of assays that can be predictive of sperm functional capacities, both under in vivo and in vitro conditions.
