ABSTRACT
The head and neck region is one of the most common sites of extranodal non-Hodgkin’s lymphoma, accounting for 10–20% of all cases of NHL. In the Western population, primary lymphomas originating in the nasal cavity and paranasal sinuses are uncommon neoplasms, accounting for 3–4% of extranodal lymphomas, but contributing to 8–16% of the lymphomas of the head and neck region. Lymphomas of the larynx are rare tumors that represent <1% of primary malignant laryngeal cancers. Several studies showed that primary extranodal head and neck lymphomas prognosis is influenced by age, histological subtype, location of disease, disease bulk, and stage. Waldeyer’s ring structures includes the tonsils in the lateral oropharyngeal wall, the nasopharyngeal lymphatic tissue, and the lingual tonsil. The traditional radiation target volume includes bilateral tonsillar fossa, nasopharynx, posterior tongue, and bilateral cervical lymph nodes. The majority are B-cell lymphomas, with diffuse large B-cell lymphoma being the most frequent histology.
