ABSTRACT
Answer: (b) Patients diagnosed at 1 year of age appear to show consistently better survival outcomes than older children, even in the presence of advanced disease at presentation. Abnormal rearrangements of chromosomes 1 and 17, and amplification of n-myc protooncogene, have been implicated in poor survival. Homer-Wright pseudorossettes are histologically diagnostic of neuroblastoma, characterized by eosinophilic neutrophils surrounded by neuroblasts (occur in 50% of cases).
