ABSTRACT
The liver is a primary site of drug metabolism, and in addition produces a number of important substances, including plasma proteins and clotting factors.
Hepatic impairment may lead to a reduced ability to metabolize a wide range of substances (leading to possible metabolic encephalopathy and/or increased adverse effects of medications) and altered production of, e.g. albumin (leading to hypoalbuminuria) and clotting factors (leading to increased risk of bleeding), and increased drug toxicity due to altered protein binding.
