ABSTRACT
The existence of adult stem cells in the human ovary has been a matter of dispute for over 100 years. If they are totipotent, such stem cells may give rise to the two distinct cell types required for the formation of ovarian primary follicles, i.e. somatic granulosa cells and female germ cells differentiating into oocytes. They may already exist in fetal ovaries, and reappear during adulthood.
