ABSTRACT

After studying this chapter, you should be able to:

describe the effects of exercise on plasma cytokines;

discuss the evidence that interleukin(IL)-6 is secreted from contracting muscle;

describe the metabolic and immunoregulatory roles of IL-6;

describe the effects of exercise on cytokine production by leukocytes;

understand the link between chronic disease risk and chronic inflammation;

describe the effects of a sedentary lifestyle and obesity on inflammation in adipose tissue;

describe the long-term health benefits of performing regular exercise;

discuss the anti-inflammatory actions of IL-6 and IL-10;

appreciate other mechanisms by which exercise can exert anti-inflammatory effects.