ABSTRACT
Patients with chronic myeloid leukaemia (CML) are often asymptomatic for a long time. They eventually develop symptoms such as tiredness, weight loss, sweats, bone pain, fever, and abdominal discomfort due to splenomegaly. All these symptoms can usually be handled with symptomatic therapy. The typical clinical culmination of CML is a fatal blast crisis. Only a small percentage of patients succumb to CML in the first and second years after diagnosis. Thereafter, however, the mortality rate is around 25% per year.
