ABSTRACT
Alzheimer’s disease (AD) is a degenerative disorder of the human CNS that normally manifests in mid to late adult life with progressive cognitive, memory and intellectual impairment. The clinical features of the disease are accompanied by widespread loss of neocortical neurones (causing cerebral atrophy), by the presence of neurofibrillary tangles (composed, among other things, of paired helical filaments) in large pyramidal neurones, and by the presence of amyloid or senile plaques (extracellular fibrous protein deposits composed of a number of proteins including the amyloid β (Aβ) peptide).
