ABSTRACT

In this chapter, the dielectric properties of solutions, particularly aqueous solutions, will be discussed. A knowledge of solution behaviour is of considerable pharmaceutical importance, in terms of both the formulation of medicaments and also the understanding of the distribution of drugs in tissues and membranes throughout the body. In particular, the aqueous solubility of a new chemical entity is one of the first physico-chemical properties to be measured during the development of a medicine, as it is considered to be a fundamental factor in the choice of dosage form and formulation.