ABSTRACT
Certain drugs are delivered to the nasal cavity because this is their intended site of action; these are administered as nasal drops or sprays for a local effect. Such drugs in clinical use include decongestants,
antibiotics and mucolytics. Due to its accessibility, the nasal cavity has also been used experimentally to investigate the safety and efficacy of gene delivery even though the gene used (the gene for the Cystic Fibrosis Transmembrane Receptor (CFTR) protein) is ultimately intended to be delivered to the lung. This is another example of local delivery since the lining of the nose was the intended site of action for the study.
