ABSTRACT
Description: Alefacept is a 91.4-kDa dimeric fusion protein consisting of the extracellular CD2 binding portion of the human leukocyte function antigen 3 (LFA-3) linked to the Fc region (consisting of the hinge, CH2 and CH3 domains) of human IgG 1. Upon administration, the product binds to and prevents lymphocyte activation and promotes a reduction in overall lymphocyte counts. The resultant immunosuppressive action blocks the immune system cells believed to play a prominent role in the pathophysiology of chronic plaque psoriasis. The product is available in two formats; both are sterile, preservative-free, lyophilized preparations supplied in vials. Amevive for i.v. administration contains 7.5 mg active ingredient/vial, whereas Amevive for i.m. administration contains 15 mg active ingredient/vial.
