ABSTRACT
It is a well-known fact that pyrogenic substances cause a rise in body temperature following intravenous administration. There are many biological and chemical pyrogens, but the most significant pyrogen encountered in the routine production of parenteral and medical devices is Gram-negative bacterial endotoxin. The terms pyrogen and endotoxin are still often interchanged, but it should be emphasized that while all endotoxins are pyrogens, not all pyrogens are endotoxins. During the manufacture of pharmaceuticals and devices, non-endotoxin pyrogens are rarely encountered.
