ABSTRACT
Recurrent minor infections are very common during early childhood due to increasing contact with other children and immaturity of the immune response. However, immunodeficiency should be considered if infections are unusually frequent or severe, are due to unusual organisms, or are associated with failure to thrive. Immunodeficiency may be congenital or acquired (e.g. HIV infection, drugs). Apart from selective IgA deficiency, congenital immunodeficiency disorders are rare. Transient hypogammaglobulinaemia may occur during infancy due to delayed maturation of immunoglobulin production. Spontaneous recovery occurs within the first 12-18 months of life.
