ABSTRACT
Phototoxicity is a chemically induced nonimmunologic skin irritation requiring
light (photoirritation). The skin response resembles an exaggerated sunburn.
The involved chemical is photoactive, and it may enter into the skin by topical
administration or it may reach the skin by the circulatory system following
ingestion or parenteral administration. Some systemically administered and
possibly topical chemicals may require metabolic conversion to become
photoactive.
