ABSTRACT
The ‘classical’ dopamine (DA) hypothesis of schizophrenia proposed that hyperactivity of DA transmission is responsible for the positive symptoms (hallucinations, delusions) observed in this disorder (Carlsson and Lindqvist, 1963). This hypothesis was supported by the correlation between clinical doses of antipsychotic drugs and their potency to block DA D2 receptors (Seeman and Lee, 1975; Creese et al, 1976) and by the psychotogenic effects of DA enhancing drugs (for review see Angrist and van Kammen, 1984; Lieberman et al, 1987).
