chapter  13
Controlled ovarian stimulation for in vitro fertilization
Pages 16

Because of the high estradiol concentrations produced by COH, in about 15-25% of the patients a positive feedback mechanism will produce a premature LH rise causing premature luteinization of the developing follicles and abandonment of the cycle. Today this is avoided by suppressing pituitary gonadotropin production by co-treating with a gonadotropin releasing hormone (GnRH) agonist. This development brought with it a number of advantages and some disadvantages and various protocols involving the use of a GnRH agonist have been developed to tailor individual requirements.