ABSTRACT
In addition, cimetidine, and to a lesser extent ranitidine, interfere with active renal tubular secretion of procainamide and metformin.
These drugs bind covalently with the enzyme H+/K+ ATPase on the gastric surface of the parietal cell. This blocks gastric acid secretion from all stimuli in a dosedependent manner, with the maximal effect after 5 days.
