Drug Typical Potency Half-life Active Half-life of dose (mg) ratio of parent metabolites metabolites drug

Longer-term dose-dependent toxicity occurs with thyroid deficiency and nephrogenic diabetes insipidus. Thiazide diuretics can precipitate toxicity by reducing lithium clearance. Although lithium interferes with acetylcholine release, there is no strong evidence that it has a major clinical effect on neuromuscular blocking agents.